OCT-4 – RMab

Oct 4 Rmab

IHC of OCT-4 on an FFPE Seminoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationOCT-4 (octamer-binding transcription factor 4) also known as POU5F1 (POU domain, class 5, transcription factor 1) is a protein that in humans is homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. Clear cell carcinoma may enter the differential diagnosis of dysgerminoma as both may grow in nests or tubules, contain clear cells, and have a prominent inflammatory infiltrate (lymphocytes in dysgerminoma and plasma cells in clear cell carcinoma).
Expression of the OCT-4 antibody is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. OCT-4 is expressed in undifferentiated pluriopotency cells, germ cells in ovary and testes. OCT-4 is a sensitive and specific marker for germ cell tumors. It is consistently detected in carcinoma in situ/ gonadoblastoma, seminomas, germinoma, dysgerminoma, and embryonal carcinoma but not in the differentiated components of nonseminomas.
Antibody TypeRabbit MonoclonalCloneEP143
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlSeminoma, Dysgerminoma, Testicular Carcinoma
PresentationOCT-4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2028PredilutedReady-To-Use3.0 ml
BSB 2029PredilutedReady-To-Use7.0 ml
BSB 2030PredilutedReady-To-Use15.0 ml
BSB 2031Concentrated1:50-1:2000.1 ml
BSB 2032Concentrated1:50-1:2000.5 ml
BSB 2033Concentrated1:50-1:2001.0 ml
BSB 2034Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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