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OCT-4 – RMab

IHC of OCT-4 on an FFPE Seminoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation OCT-4 (octamer-binding transcription factor 4) also known as POU5F1 (POU domain, class 5, transcription factor 1) is a protein that in humans is homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. Clear cell carcinoma may enter the differential diagnosis of dysgerminoma as both may grow in nests or tubules, contain clear cells, and have a prominent inflammatory infiltrate (lymphocytes in dysgerminoma and plasma cells in clear cell carcinoma).
Expression of the OCT-4 antibody is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. OCT-4 is expressed in undifferentiated pluriopotency cells, germ cells in ovary and testes. OCT-4 is a sensitive and specific marker for germ cell tumors. It is consistently detected in carcinoma in situ/ gonadoblastoma, seminomas, germinoma, dysgerminoma, and embryonal carcinoma but not in the differentiated components of nonseminomas.
Antibody Type Rabbit Monoclonal Clone EP143
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Seminoma, Dysgerminoma, Testicular Carcinoma
Presentation OCT-4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2028 Prediluted Ready-To-Use 3.0 ml
BSB 2029 Prediluted Ready-To-Use 7.0 ml
BSB 2030 Prediluted Ready-To-Use 15.0 ml
BSB 2031 Concentrated 1:50-1:200 0.1 ml
BSB 2032 Concentrated 1:50-1:200 0.5 ml
BSB 2033 Concentrated 1:50-1:200 1.0 ml
BSB 2034 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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