IHC of MyoD1 on an FFPE Rhabydomyosarcoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||MyoD1 belongs to a family of proteins known as myogenic regulatory factors (MRFs) and has a key role in regulating muscle differentation. These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MyoD1 is expressed in activated satellite cells, but not in quiescent satellite cells. In development, MyoD1 commits mesoderm cells to a skeletal lineage, and then regulates that process. It may also play a role in muscle repair.
In abnormal tissues, MyoD1 labels tumor cells in Rhabdomyosarcoma and is one of the earliest markers of myogenic commitment.
|Antibody Type||Rabbit Monoclonal||Clone||EP212|
|Localization||Nuclear||Control||Fetal Muscle, Rhabdomyosarcoma|
|Presentation||MyoD1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|