MUC4 – RMab

Ihc Of Muc-4 On An Ffpe Colon Tissue

IHC of MUC-4 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.        
Summary and ExplanationMucin 4 (MUC4) is a mucin protein that in humans is encoded by the MUC4 gene. Like other mucins, MUC4 is a high-molecular weight glycoprotein. MUC4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein. MUC4 antibody labels normal epithelial cells in the trachea, GI tract and prostate, but not in the pancreas.MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as endometriosis and inflammatory bowel disease. An abnormal expression of MUC4 has been reported in various carcinomas of the colon, pancreas, breast, and ovaries. Increased expression of MUC4 has been observed in pancreatic carcinoma and cervical squamous carcinoma. MUC4 is helpful in differentiating lung adenocarcinoma (positive) from malignant mesothelioma (negative). Additionally, MUC4 is useful in the identification of low-grade fibromyxoid sarcoma (LGFMS), and sclerosing epithelioid fibrosarcoma. MUC4 expression is also detected in the glandular component of biphasic synovial sarcomas.
 Antibody TypeRabbitt MonoclonalCloneEP256
 IsotypeIgGReactivityParaffin, Frozen
Prostate, Liver, Kidney, Bladder TCC, Pancreatic Carcinoma and Cervical Squamous Carcinoma
PresentationMUC4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2552PredilutedReady-To-Use3.0 ml
BSB 2553PredilutedReady-To-Use7.0 ml
BSB 2554PredilutedReady-To-Use15.0 ml
BSB 2555Concentrated1:25-1:1000.1 ml
BSB 2556Concentrated1:25-1:1000.5 ml
BSB 2557Concentrated1:25-1:1001.0 ml
BSB 2555Control Slides 5
 Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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