IHC of MSH6 on an FFPE Colon Carcinoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | MSH6 is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset Colorectal Carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterparts. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | 44 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1 | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | Control | Colon Mucosa, Colon Carcinoma | |||||||||||||||||||||||||||||||||
| Presentation | MSH6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
| Availability |
| |||||||||||||||||||||||||||||||||||
| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
