MSH6 – MMab

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Ihc Of Msh6 On An Ffpe Colon Carcinoma Tissue

IHC of MSH6 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationMSH6 is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset Colorectal Carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterparts.
Antibody TypeMouse MonoclonalClone44
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationNuclearControlColon Mucosa, Colon Carcinoma
PresentationMSH6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6142PredilutedReady-To-Use3.0 ml
BSB 6143PredilutedReady-To-Use7.0 ml
BSB 6144PredilutedReady-To-Use15.0 ml
BSB 6145Concentrated1:50-1:2000.1 ml
BSB 6146Concentrated1:50-1:2000.5 ml
BSB 6147Concentrated1:50-1:2001.0 ml
BSB 6148Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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