MLH1 – MMab

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Ihc Of Mlh1 On An Ffpe Colon Carcinoma Tissue

IHC of MLH1 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationMLH1 is a mismatch repair gene of around 87 kDa, commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. In a high proportion of patients with microsatellite instability (MSI-H), the MLH1 protein is typically deficient. This protein deficiency is linked to the autosomal dominant condition of Hereditary Non-Polyposis Colon Cancer. The anti-MLH1antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite stable counterparts.
Antibody TypeMouse MonoclonalCloneG168-728
IsotypeIgG2a/KReactivityParaffin, Frozen
LocalizationNuclearControlTestis, Tonsil, Colon, Kidney, Colon Carcinoma
PresentationAnti-MLH1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5764PredilutedReady-To-Use3.0 ml
BSB 5765PredilutedReady-To-Use7.0 ml
BSB 5766PredilutedReady-To-Use15.0 ml
BSB 5767Concentrated1:10-1:500.1 ml
BSB 5768Concentrated1:10-1:500.5 ml
BSB 5769Concentrated1:10-1:501.0 ml
BSB 5770Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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