Mesothelin – RMab

Ihc Of Mesothelin On An Ffpe Ovarian Tissue

IHC of Mesothelin on an FFPE Ovarian Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationMesothelin was first identified by its reactivity with monoclonal antibody K1. The mesothelin gene encodes a precursor protein that is processed to yield mesothelin, which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-KDa shed fragment named megakaryocyte-potentiating factor (MPF). Its biological function is not known, but recent studies have shown that mesothelin forms a strong and specific complex with MUC16, which has been suggested to be the basis of ovarian cancer metastasis.
Mesothelin is present on normal mesothelial cells lining the pleura, peritoneum, and pericardium. In tumors, overexpression of Mesothelin has been observed in mesotheliomas, and other tumors including ovarian, pancreatic carcinomas, and cholangiocarcinoma.
Antibody TypeRabbit MonoclonalCloneEP140
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlCervix, Tonsil, Mesothelioma, Ovarian Cancer
PresentationMesothelin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6919PredilutedReady-To-Use3.0 ml
BSB 6920PredilutedReady-To-Use7.0 ml
BSB 6921PredilutedReady-To-Use15.0 ml
BSB 6922Concentrated1:50-1:2000.1 ml
BSB 6923Concentrated1:50-1:2000.5 ml
BSB 6924Concentrated1:50-1:2001.0 ml
BSB 6925Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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