MDR-1 – RMab

SKU: bd2630d721e8 Categories: , ,

Mdr-1-20X-1Gel02-23-1 Adrenal

IHC of MDR-1 on an FFPE Adrenal Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and ExplanationP-glycoprotein 1, also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243), functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance phenomenon observed in human cancer cells following prolonged chemotherapy. The classic form of multiple drug resistance is associated with an increase in the MDR protein, but not in all cases. MDR-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug transport pump that transports a variety of drugs from the brain back into the blood.

MDR-1 is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.

Antibody TypeRabbit MonoclonalCloneEP271
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlSkeletal Muscle, Kidney, Adrenal, Liver
PresentationMDR-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2531PredilutedReady-To-Use3.0 ml
BSB 2532PredilutedReady-To-Use7.0 ml
BSB 2533PredilutedReady-To-Use15.0 ml
BSB 2534Concentrated1:50-1:2000.1 ml
BSB 2535Concentrated1:50-1:2000.5 ml
BSB 2536Concentrated1:50-1:2001.0 ml
BSB 2537Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

Related products

Skip to content