MDR-1 – MMab

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Ihc Of Mdr-1 On An Ffpe Tissue

IHC of MDR-1 on an FFPE FFPE Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationP-glycoprotein 1, also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243), functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance phenomenon observed in human cancer cells following prolonged chemotherapy. The classic form of multiple drug resistance is associated with an increase in the MDR protein, but not in all cases. MDR-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug transport pump that transports a variety of drugs from the brain back into the blood.

MDR-1 is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.

Antibody TypeMouse MonoclonalCloneJSB-1
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmicControlSkeletal Muscle, Kidney, Adrenal, Liver
PresentationMDR-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6898PredilutedReady-To-Use3.0 ml
BSB 6899PredilutedReady-To-Use7.0 ml
BSB 6900PredilutedReady-To-Use15.0 ml
BSB 6901Concentrated1:25-1:1000.1 ml
BSB 6902Concentrated1:25-1:1000.5 ml
BSB 6903Concentrated1:25-1:1001.0 ml
BSB 6904Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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