Langerin / CD207 – RMab

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Ihc Of Langerin On An Ffpe Prostate Tissue

IHC of Langerin on a FFPE Prostate Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Langerin is a type II transmembrane cell surface receptor produced by Langerhans Cells, which are immature dendritic cells of the epidermis and mucosa. Epidermal LCs possess strong immunohistochemistry capacity and play a central role in the initiation and regulation of immune responses. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannosebinding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.

Human spleen, lymph node, thymus, liver, lung and heart express langerin protein. Langerin protein expression has utility in differentiating Langerhans cell histiocytosis from other non-Langerhans cell histiocytic proliferations.

Antibody TypeRabbit MonoclonalCloneEP349
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlSkin, Prostate, Breast, Liver, Cervix, Salivary Gland, Langerhans Histiocytosis
PresentationLangerin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3370PredilutedReady-To-Use3.0 ml
BSB 3371PredilutedReady-To-Use7.0 ml
BSB 3372PredilutedReady-To-Use15.0 ml
BSB 3373Concentrated1:50-1:2000.1 ml
BSB 3374Concentrated1:50-1:2000.5 ml
BSB 3375Concentrated1:50-1:2001.0 ml
BSB 3376Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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