TIA-1 – MMab

Ihc Of Tia-1 On An Ffpe Tonsil Tissue

IHC of TIA-1 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationTIA-1 (T-cell intracytoplasmic antigen) is a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing. The expression of TIA-1 has been studied in Anaplastic Large Cell Lymphomas (ALCL), NK-cell Lymphomas, Peripheral T-cell Lymphomas, T-cell Lymphocytosis, B-cell Lymphomas and Lymphoblastic Leukemia, Hodgkin’s, etc. Studies show that 60 to 70% of Anaplastic Large Cell Lymphomas react with TIA-1. TIA-1 reacts with most Large Granular Lymphocytic Leukemias, Hepatosplenic T-cell Lymphomas, intestinal T-cell Lymphomas, NK-like T-cell Lymphomas, NK-cell Lymphomas, nasal T/NK-cell Lymphomas, subcutaneous T-cell Lymphomas and Pulmonary Angiocentric Lymphomas of T- or NK-phenotype. All B-cell Lymphomas, Hodgkin’s and Lymphoblastic Leukemias are negative for TIA-1.
Antibody TypeMouse MonoclonalCloneTIA-1
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmic (Granular)ControlTonsil, Spleen, Anaplastic Large Cell Lymphoma
PresentationTIA-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6352PredilutedReady-To-Use3.0 ml
BSB 6353PredilutedReady-To-Use7.0 ml
BSB 6354PredilutedReady-To-Use15.0 ml
BSB 6355Concentrated1:25-1:1000.1 ml
BSB 6356Concentrated1:25-1:100<0.5 ml
BSB 6357Concentrated1:25-1:100<1.0 ml
BSB 6358Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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