Glucagon – Rabbit Polyclonal

Glucagon20X 1Wfd22 14 2 Pancreas

IHC of Glucagon on an FFPE Pancreas Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationGlucagon is a 29-amino acid polypeptide acting as an important hormone in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Abnormally-elevated levels of glucagon may be caused by pancreatic tumors such as glucagonoma, symptoms of which include necrolytic migratory erythema (NME), elevated amino acids and hyperglycemia. It may occur alone or in the context of Multiple Endocrine Neoplasia Type 1. Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas. Studies show that approximately 80% of glucagonomas are malignant and these patients have a syndrome most often initially recognized by dermatologists. Symptoms include necrolytic migratory erythema as well as diabetes, anemia, stomatitis, weight loss, frequent venous thromboses, and in some instances, diarrhea and psychiatric disturbances. The diagnosis may be readily confirmed by the demonstration of elevated plasma glucagon concentration.
Antibody TypeRabbit PolyclonalCloneN/A
IsotypeN/AReactivityParaffin, Frozen
LocalizationCytoplasmicControlColon, Pancreas
PresentationGlucagon is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5575Tinto PredilutedReady-To-Use3.0 ml
BSB 5576Tinto PredilutedReady-To-Use7.0 ml
BSB 5577Tinto PredilutedReady-To-Use15.0 ml
BSB 5578Concentrated1:50-1:2000.1 ml
BSB 5579Concentrated1:50-1:2000.5 ml
BSB 5580Concentrated1:50-1:2001.0 ml
BSB 5581Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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