Factor XIIIa – RMab

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Ihc Of Factor Xiiia On An Ffpe Placenta Tissue

IHC of Factor XIIIa on an FFPE Placenta Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationFactor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into Factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells present in the placenta, uterus, and prostate; it is also present in monocytes, macrophages and dermal dendritic cells. Anti-Factor XIIIa has been found to be useful in differentiating between Dermatofibroma (90% (+)), Dermatofibrosarcoma Protuberans (25%(+)) and Desmoplastic Malignant Melanoma (0%(+)). Factor XIIIa positivity is also seen in Capillary Hemagioblastoma (100%(+)), Hemangioendothelioma (100%(+)), Hemangiopericytoma (100%(+)), Xanthogranuloma (100%(+)), Xanthoma (100(+)), Hepatocellular Carcinoma (93%(+)), Glomus Tumor (80%(+)), and Meningioma 80%(+)).
Antibody TypeRabbit MonoclonalCloneEP292
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlPlacenta, Testis, Tonsil, Skin, Colon
PresentationAnti-Factor XIIIa is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5505PredilutedReady-To-Use3.0 ml
BSB 5506PredilutedReady-To-Use7.0 ml
BSB 5507PredilutedReady-To-Use15.0 ml
BSB 5508Concentrated1:50-1:2000.1 ml
BSB 5509Concentrated1:50-1:2000.5 ml
BSB 5510Concentrated1:50-1:2001.0 ml
BSB 5511Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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