DOG-1 – RMab

SKU: 48e623787ba6 Categories: , , , , ,

3. Ihc Of Dog 1 On A Ffpe Gist Tisse Webpage

IHC of DOG-1 on an FFPE GIST Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

DOG1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody.

DOG1 identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST diagnosis.

Antibody TypeRabbit MonoclonalCloneEP332
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlSalivary Gland, Breast, GIST
PresentationDOG-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2901PredilutedReady-To-Use3.0 ml
BSB 2902PredilutedReady-To-Use7.0 ml
BSB 2903PredilutedReady-To-Use15.0 ml
BSB 2904Concentrated1:25-1:1000.1 ml
BSB 2905Concentrated1:25-1:1000.5 ml
BSB 2906Concentrated1:25-1:1001.0 ml
BSB 2907Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

Related products

Skip to content