Desmoglein-3 – RMab

3. Ihc Of Desmoglein 3 On A Ffpe Squamous Cell Carcinoma Tissue Webpage

IHC of Desmoglein-3 on an FFPE Squamous Cell Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Desmoglein 3 is a protein that is encoded by the DSG3 gene on Chromosome 18. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component ofdesmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Desmoglein 3 has been cited as a superior marker for Lung Squamous Cell Carcinomas, and helps distinguish lung squamous cell carcinoma cases from lung adenocarcinoma. Studies have also shown that a panel consisiting of Desmoglein-3 utilized with Napsin A can be a useful Immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes. Lung cases that are typically positive for Desmoglein 3 tend to have a poor clinical outcome.

Antibody TypeRabbit MonoclonalCloneEP306
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Skin, Cervix, Cervical Carcinoma, Lung Squamous Cell Carcinoma
PresentationDesmoglein-3 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2894PredilutedReady-To-Use3.0 ml
BSB 2895PredilutedReady-To-Use7.0 ml
BSB 2896PredilutedReady-To-Use15.0 ml
BSB 2897Concentrated1:50-1:2000.1 ml
BSB 2898Concentrated1:50-1:2000.5 ml
BSB 2899Concentrated1:50-1:2001.0 ml
BSB 2900Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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