Cytokeratin Cocktail AE1 & AE3 – MMab

Ck Cocktail Ae1 Ae3 Mmab

IHC of Cytokeratin Cocktail AE1 & AE3 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: the low-weight, acidic Type I cytokeratins and the high-weight, basic or neutral Type II cytokeratins. Cytokeratins are usually found in pairs comprising a Type I cytokeratin and a Type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue-specific. Cytokeratin cocktail AE1/AE3 is well suited to distinguish Epithelial Carcinoma from Non-epithelial malignancies and is used to aid Epithelial Tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin-containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues. This antibody has shown high sensitivity and specificity in recognizing epithelial cells of neoplastic origin.
Antibody TypeMouse MonoclonalCloneAE1 & AE3
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmicControlProstate, Skin, Colon, Stomach, Salivary Gland
PresentationCytokeratin AE1/AE3 is cocktail of a mouse monoclonal antibodies derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5428PredilutedReady-To-Use3.0 ml
BSB 5429PredilutedReady-To-Use7.0 ml
BSB 5430PredilutedReady-To-Use15.0 ml
BSB 5431Concentrated1:100-1:5000.1 ml
BSB 5432Concentrated1:100-1:5000.5 ml
BSB 5433Concentrated1:100-1:5001.0 ml
BSB 5434Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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