IHC of Cytokeratin 8 on an FFPE Colon Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Cytokeratin 8, also known as type II cytoskeletal 8, is a protein that is often paired with Cytokeratin 18. They are perhaps the most commonly found products of the intermediate filament gene family, and are expressed in single-layer epithelial tissues of the body. Cytokeratin 8 is an intermediate filament protein produced early in embryogenesis. Anti-Cytokeratin 8 can be used to detect Adenocarcinomas with simple epithelium origin. It can be used to distinguish between Duct (peripheral staining) from Lobular (perinuclear staining) Breast Carcinoma. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP17 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Colon, Prostate, Kidney, Liver, Colon Carcinoma | |||||||||||||||||||||||||||||||||
| Presentation | CK8 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
