Cytokeratin 5 & ERG – RMab

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Cytokeratin 5 Erg1

IHC of cytokeratin & ERG on an FFPE Prostate Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCytokeratin 5 is a type II cytokeratin found in squamous cell epithelium, myoepithelial cells of the breast and the basal cells of the prostate. Transcriptional regulator ERG is a nuclear protein that binds purine-rich sequences. ERG is expressed at higher levels in early myelocytes than in mature lymphocytes, and thus ERG may act as a regulator of differentation of early hematopoietic cells. ERG can fuse with TMPRSS2 protein to form an oncogenic fusion gene commonly found in prostate cancer. Eighty percent of prostate tumors contain genomic fusions of TMPRSS2 and members of the ETS family of transcription factors.
Cytokeratin 5 is expressed in most epithelial mesotheliomas but not by most pulmonary adenocarcinomas and can be used to differentiate between the two. ERG antibody labels prostate cancer cells, endothelial cells, and lymphocyes.
Antibody TypeRabbit MonoclonalCloneEP24/EP211
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlBreast, Prostate, Prostate Cancer
PresentationCK5 & ERG is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6611PredilutedReady-To-Use3.0 ml
BSB 6612PredilutedReady-To-Use7.0 ml
BSB 6613PredilutedReady-To-Use15.0 ml
BSB 6614Concentrated1:25-1:1000.1 ml
BSB 6615Concentrated1:25-1:1000.5 ml
BSB 6616Concentrated1:25-1:1001.0 ml
BSB 6617Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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