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Cytokeratin 5, 6, & ERG – RMab

SKU: 8734afa2d3b3 Categories: , ,

IHC of Cytokeratin 5, 6 & ERG on an FFPE Breast Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratin 5 is a type II cytokeratin found in squamous cell epithelium, myoepithelial cells of the breast and the basal cells of the prostate. Cytokeratin 6 is a type II cytokeratin known for its strong induction in stratified epithelia that features an enhanced cell proliferation rate or abnormal differentiation during wound healing. ERG is expressed at higher levels in early myelocytes than in mature lymphocytes, and thus ERG may act as a regulator of differentation of early hematopoietic cells. ERG can fuse with TMPRSS2 protein to form an oncogenic fusion gene commonly found in prostate cancer.
Cytokeratin 5 is expressed in most epithelial mesotheliomas but not by most pulmonary adenocarcinomas and can be used to differentiate between the two. Together, CK 5 & 6 can be used to differeniate Mesothelioma (positive) from Lung Carcinoma (negative) or metastatic carcinoma (negative), and can also be used to distinguish between Ductal Hyperplasia of the breast (positive) from Solid Papillary DCIS (negative). ERG antibody labels prostate cancer cells, endothelial cells, and lymphocyes.
Antibody Type Rabbit Monoclonal Clone EP24/EP67/EP111
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Breast and Prostate Carcinomas
Presentation CK5, CK6 & ERG is a rabbit monoclonal antibody cocktail derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6618 Prediluted Ready-To-Use 3.0 ml
BSB 6619 Prediluted Ready-To-Use 7.0 ml
BSB 6620 Prediluted Ready-To-Use 15.0 ml
BSB 6621 Concentrated 1:10-1:50 0.1 ml
BSB 6622 Concentrated 1:10-1:50 0.5 ml
BSB 6623 Concentrated 1:10-1:50 1.0 ml
BSB 6624 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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