Cytokeratin 17 – RMab


IHC of CK 17 on an FFPE Cervical Cancer Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCytokeratin 17 is a Type I cytokeratin with a MW of 46 kD found sometimes in association with Cytokeratin 7. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type Pachyonychia Congenita and Steatocystoma Multiplex. Cytokeratin 17 antibody has been used to distinguish immature Cervical Squamous Metaplasia from high grade Cervical Intraepithelial Neoplasia (CIN III). Anti-CK 17 also labels myoepithelial cells in the benign breast tissue. CK 17 labeling of Breast Carcinoma cells (so-called basal phenotype) has been associated with a poor prognosis.
Antibody TypeRabbit MonoclonalCloneEP98
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlSkin, Testis, Breast, Cervix, Colon, Salivary Gland, Cervical Carcinoma, Bladder TCC, Transitional Cell Carcinoma
PresentationCytokeratin 17 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6184PredilutedReady-To-Use3.0 ml
BSB 6185PredilutedReady-To-Use7.0 ml
BSB 6186PredilutedReady-To-Use15.0 ml
BSB 6187Concentrated1:25-1:1000.1 ml
BSB 6188Concentrated1:25-1:1000.5 ml
BSB 6189Concentrated1:25-1:1001.0 ml
BSB 6190Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
* The Cytokeratin 17 antibody, clone EP98, has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409.

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