Cyclin B1 – RMab

SKU: c5b0396ff13d Categories: , , , ,

Ihc Of Cyclin B1 On An Ffpe Cervical Cancer Tissue

IHC of Cyclin B1 on an FFPE Cervical Cancer Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCyclin B1 is a regulatory protein involved with mitosis. It complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit mitosis. Its activation is well regulated, and positive feedback loops ensure that once the cyclin B1-Cdk1 complex is activated it is not deactivated. Cyclin B1-Cdk1 is involved in the early events of mitosis, such as chromosome condensation, nuclear envelope breakdown, and spindle pole assembly. Before mitosis almost all cyclin B1 in the cell is located in the cytoplasm, but in late prophase it relocates to the nucleus. At the end of mitosis, cyclin B1 is targeted for degradation by the APC through its APC localization sequence, permitting the cell to exit mitosis.
Cyclin B1 has been shown to be overexpressed in various tumor types.
Antibody TypeRabbit MonoclonalCloneRBT-B1
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlCervix, HSIL Cervix
PresentationCyclin B1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6548PredilutedReady-To-Use3.0 ml
BSB 6549PredilutedReady-To-Use7.0 ml
BSB 6550PredilutedReady-To-Use15.0 ml
BSB 6551Concentrated1:50-1:2000.1 ml
BSB 6552Concentrated1:50-1:2000.5 ml
BSB 6553Concentrated1:50-1:2001.0 ml
BSB 6554Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

Related products

Skip to content