Collagen Type IV – MMab

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Collagen Iv Mmab

IHC of Collagen Type IV on an FFPE Skin Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCollagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% of the total protein content. Collagen IV is a major constituent of the basement membranes, along with laminins and enactins. It is composed of the alpha 1 IV chain and alpha 2 IV chain in a 2:1 ratio. It can form insoluble fibers with high tensile strength. Normal tissue stains with this antibody in a manner consistent with the sites of mesenchymal elements and epithelial basal laminae. Antibody to collagen IV is useful in detecting the loss of parts of basement membrane in carcinomas. Collagen IV can also be useful in the classification of soft tissue tumors; Schwanomas, Leiomyomas, and their well-differentiated malignant counterparts usually immunoreact to this antibody. The vascular nature of neoplasms, Hemangiopericytoma, Angiosarcoma and Epithelioid Hemangioendothelioma can be observed with this antibody.
Antibody TypeMouse MonoclonalCloneCIV22
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlMuscle, Lung
PresentationCollagen Type IV is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Special NoteCollagen Type IV antibody requires the use of ImmunoDNA Digestor (Cat.#’s BSB 0108, BSB 0109, BSB 0110, BSB 0111, BSB 0112) or similar Proteinase K based product as antigen retriever.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5351PredilutedReady-To-Use3.0 ml
BSB 5352PredilutedReady-To-Use7.0 ml
BSB 5353PredilutedReady-To-Use15.0 ml
BSB 5354Concentrated1:50-1:2000.1 ml
BSB 5355Concentrated1:50-1:2000.5 ml
BSB 5356Concentrated1:50-1:2001.0 ml
BSB 5357Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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