|For In Vitro Diagnostic Use
|Summary and Explanation
|The Clusterin protein, also known as Apolipoprotein J, is a 75-80 kDa disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid. It is a stress-induced cytoprotective chaperone protein regulated by HSF1 and functions similarly to a small heat-shock protein. Clusterin is distributed widely in human tissues and fluids, including normal epithelial cells, plasma, cerebrospinal fluid, breast milk, semen and urine. Clusterin has been implicated in a variety of activities including programmed cell death, regulation of complement mediated cell lysis, membrane recycling, cell-cell adhesion, and src induced transformation. As part of the attack complex of complement, it acts as a complement inhibitor.
Clusterin is expressed in a wide variety of hematopoietic and non-hematopoietic tumors. Overexpression of Clusterin is associated with poor prognosis in breast cancer and chemosensitivity in cervical cancer.
|Tonsil, Lymph Node, Placenta, Colon, Kidney, Brain, Liver
|Clusterin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.