CD8 – MMab

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IHC of CD8 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCD8 is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule that is specific for the Class I MHC protein. To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. CD8 is a T-cell marker for the detection of cytotoxic/suppressor cells of blood lymphocytes. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null cells and bone marrow cells. This antibody is used to distinguish between reactive and neoplastic T-cells.
Antibody TypeMouse MonoclonalCloneC8/144B
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationMembranousControlTonsil, Lymph Node
PresentationCD8 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5169PredilutedReady-To-Use3.0 ml
BSB 5170PredilutedReady-To-Use7.0 ml
BSB 5171PredilutedReady-To-Use15.0 ml
BSB 5172Concentrated1:250-1:10000.1 ml
BSB 5173Concentrated1:250-1:10000.5 ml
BSB 5174Concentrated1:250-1:10001.0 ml
BSB 5175Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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