CD45R – MMab

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Ihc Of Cd45R On An Ffpe Tonsil Tissue

IHC of CD45R on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCD45R contains an extracellular domain, a single transmembrane segment and two tandem intracyto-plasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T and B-cell antigen-receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen-receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine-receptor signaling. CD45R represents a restricted form of the CD45 family, which primarily recognizes only cells of B lineage from proB-cell through mature B lymphocytes and, prior to the availability of anti-CD19 MAbs, was commonly used as a pan B-cell marker. It also reacts with certain activated T-cells, as well as non-MHC restricted lytically active lymphokine-activated killer (LAK) cells. MB1 antibody stains preferentially B-cells and their neoplasms but is less specific, as it will also react with some T-cell Lymphomas and Non-lymphoid Tumors. The antigen for this antibody is in the membrane of all B-cells with the exception of plasma cells and some mature T-cells.
Antibody TypeMouse MonoclonalCloneMB1
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationMembranousControlTonsil, Lymph Node
PresentationCD45R is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6254PredilutedReady-To-Use3.0 ml
BSB 6255PredilutedReady-To-Use7.0 ml
BSB 6256PredilutedReady-To-Use15.0 ml
BSB 6257Concentrated1:25-1:1000.1 ml
BSB 6258Concentrated1:25-1:1000.5 ml
BSB 6259Concentrated1:25-1:1001.0 ml
BSB 6260Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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