CD45 – MMab

IHC of CD45 on an FFPE Tonsil Tissue

IHC of CD45 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation The CD45 antigen is a protein which was originally called Leukocyte Common Antigen. It is a Type I transmembrane protein which is in various forms present on all differentiated hematopoietic cells except erythrocytes and assists in the activation of those cells (a form of co-stimulation). It is expressed in Lymphomas, B-cell Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and Acute Non-lymphocytic Leukemia. CD45 is a monoclonal antibody that is routinely used to aid in the differential diagnosis of undifferentiated neoplasms, whenever malignant Lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody; thus, a positive result is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin’s Disease, some T-cell Lymphomas and some Leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is exclusively expressed by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes, erythrocytes and plasma cell precursors.
Antibody Type Mouse Monoclonal Clone 2B11 & PD7/26
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Membranous Control Tonsil, Lymph Node, Spleen, Thymus
Presentation CD45 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5246 Prediluted Ready-To-Use 3.0 ml
BSB 5247 Prediluted Ready-To-Use 7.0 ml
BSB 5248 Prediluted Ready-To-Use 15.0 ml
BSB 5249 Concentrated 1:250-1:1000 0.1 ml
BSB 5250 Concentrated 1:250-1:1000 0.5 ml
BSB 5251 Concentrated 1:250-1:1000 1.0 ml
BSB 5252 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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