Products

CD34 – MMab

Cd34 Mmab

IHC of CD34 on an FFPE Kidney Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCD34 functions as a cell-cell adhesion factor and cell-surface glycoprotein. It may also mediate the attachment of stem cells to bone marrow extracellular matrixes or directly to stromal cells. Cells expressing CD34 are normally found in the umbilical cord and bone marrow as hematopoletic cells, and in vascular endothelium. In addition to stem cell recognition, CD34 is expressed by vascular endothelium; it appears that proliferating endothelial cells express this molecule in greater amounts than resting cells. In comparison to factor VIII R Antigen, CD34 stains are stronger and appear to be more sensitive in nature. In tumors, CD34 is found in Alveolar Soft Part Sarcoma, pre B-ALL (positive in 75%), AML(40%), AMLM7 (most), Dermatofibrosarcoma Protuberans, Gastrointestinal Stromal Tumors, Giant Cell Fibroblastoma, Granulocytic Sarcoma, Kaposi’s Sarcoma, Liposarcoma, Malignant Fibrous Histiocytoma, Malignant Peripheral Nerve Sheath tumors, Mengingeal Hemangiopericytomas, Meningiomas, Neurofibromas, Schwannomas, and Papillary Thyroid Carcinoma. A negative CD34 may exclude Ewing’s Sarcoma/PNET, Myofibrosarcoma of the breast, and Inflammatory Myofibroblastic tumors of the stomach.
Antibody TypeMouse MonoclonalCloneQBEnd/10
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Placenta, Appendix
PresentationCD34 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5225PredilutedReady-To-Use3.0 ml
BSB 5226PredilutedReady-To-Use7.0 ml
BSB 5227PredilutedReady-To-Use15.0 ml
BSB 5228Concentrated1:100-1:5000.1 ml
BSB 5229Concentrated1:100-1:5000.5 ml
BSB 5230Concentrated1:100-1:5001.0 ml
BSB 5231Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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