CD25 – MMab

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Cd25 Mmab

IHC of CD25 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCD25 is the alpha chain of the IL-2 receptor. It is a Type I transmembrane protein present on activated T-cells, activated B-cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. It is expressed in most B-cell neoplasms, some Acute Non-lymphocytic Leukemias, and Neuroblastomas. Expression of CD25 is a reliable diagnostic tool for distinguishing neoplastic mast-cell aggregates from reactive proliferations, and has, therefore, recently become a minor criterion for the diagnosis of Systemic Mastocytosis (SM). Anti-CD25 antibodies have also been useful in identifying mast cells in skin biopsies in the setting of Urticaria Pigmentosa, which is predictive of Systemic Mastocytosis. Quantitation of regulatory T-cells (Treg) in the setting of hepatocellular carcinoma has been used as an independent predictive factor for tumor recurrence after hepatic resection for HCC. Also, the percentage of tumor-infiltrating CD25+FOXP3+ regulatory T-cells among tumor cells, inside tumor parenchyma and at its periphery are significantly higher in recurrent Cutaneous Melanoma than in Non-recurrent Melanoma.
Antibody TypeMouse MonoclonalClone4C9
IsotypeIgG2bReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Small Bowel, Spleen, Mastocytosis, Hodgkin’s Lymphoma
PresentationCD25 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6317PredilutedReady-To-Use3.0 ml
BSB 6318PredilutedReady-To-Use7.0 ml
BSB 6319PredilutedReady-To-Use15.0 ml
BSB 6320Concentrated1:10-1:500.1 ml
BSB 6321Concentrated1:10-1:500.5 ml
BSB 6322Concentrated1:10-1:501.0 ml
BSB 6323Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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