|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Cadherin-6 is a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. It is a type I cadherin and may play a role in kidney development as well as endometrium and placenta formation.
Cadherin-6 is highly expressed in kidney and the central nervous system. It has been found to be related to fetal kidney development and has been identified as a major cadherin in renal proximal tubules where conventional renal cell carcinoma originates. The expression of Cadherin-6 is associated with tumor progression in renal cell carcinoma.
|Antibody Type||Rabbit Monoclonal||Clone||EP217|
|Localization||Membranous||Control||Kidney, Renal Cell Carcinoma|
|Presentation||Cadherin-6 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|