IHC of Li-Cadherin on an FFPE Colon Carcinoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||LI-Cadherin, also known as Cadherin-17, is part of the cadherin superfamily and is a calcium-dependent, membrane-associated glycoprotein. Cadherins are responsible for mediating cell-cell adhesion and are important for the structural integrity of epithelia. LI-Cadherin consists of an extracellular region containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. It is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. It may play a role in the morphological organization of liver and intestine.
In normal tissues, the LI-Cadherin antibody labels epithelial cells in the gastrointestinal tract and pancreatic duct, but not in kidney, liver and other tissues. In tumors, LI-Cadherin is expressed on adenocarcinoma of the digestive system, including liver cancer. It is a sensitve marker for the identification of gastric intestinal metaplasia and well differentiated adenocarcinomas.
|Antibody Type||Rabbit Monoclonal||Clone||EP86|
|Presentation||LI-Cadherin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|