IHC of C4d on an FFPE Rejected Kidney Transplant Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Complement component 4, or C4, plays a central role in the complement system. C4d is the final proteolytic remnant of deposited C4b on endothelium and remains covalently attached to endothelium for little more than a week. It is easily detectable by Immunohistochemistry. Anti-C4d combined with anti-C3d can be utilized as a tool for diagnosis of AR (Acute Rejection) and warrant prompt and aggressive anti-rejection treatment. C4d can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Polyclonal | Clone | Polyclonal | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic, Membranous | Control | Tonsil, Lymph Node, Colon, Spleen, Kidney, Rejected Kidney Transplant | |||||||||||||||||||||||||||||||||
| Presentation | C4d is a Rabbit Polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
