Actin, Smooth Muscle

Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationActin is a major component of the cytoskeleton and is present in every cell type. Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. In vertebrates 3 main groups of actin isoforms (alpha, beta and gamma) have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Smooth-Muscle Actin antibody does not stain cardiac or skeletal muscle; however, it will stain myofibroblasts and myoepithelial cells. This antibody could be used together with Muscle-Specific Actin to distinguish Leiomyosarcoma from Rhabdomyosarcoma. In most cases of Rhabdomyosarcoma, this antibody gives negative results whereas M. S. Actin is positive in the rhabdomyoblasts. Leiomyosarcomas are positive with both M. S. Actin and S. M. Actin antibodies.
Antibody TypeMouse MonoclonalCloneBSB-15
IsotypeIgG2a/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlAppendix, Uterus
PresentationS. M. Actin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5029PredilutedReady-To-Use3.0 ml
BSB 5030PredilutedReady-To-Use7.0 ml
BSB 5031PredilutedReady-To-Use15.0 ml
BSB 5032Concentrated1:250-1:10000.1 ml
BSB 5033Concentrated1:250-1:10000.5 ml
BSB 5034Concentrated1:250-1:10001.0 ml
BSB 5035Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.


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