Actin, Smooth Muscle

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Actin is a major component of the cytoskeleton and is present in every cell type. Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. In vertebrates 3 main groups of actin isoforms (alpha, beta and gamma) have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Smooth-Muscle Actin antibody does not stain cardiac or skeletal muscle; however, it will stain myofibroblasts and myoepithelial cells. This antibody could be used together with Muscle-Specific Actin to distinguish Leiomyosarcoma from Rhabdomyosarcoma. In most cases of Rhabdomyosarcoma, this antibody gives negative results whereas M. S. Actin is positive in the rhabdomyoblasts. Leiomyosarcomas are positive with both M. S. Actin and S. M. Actin antibodies.
Antibody Type Mouse Monoclonal Clone BSB-15
Isotype IgG2a/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Appendix, Uterus
Presentation S. M. Actin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5029 Prediluted Ready-To-Use 3.0 ml
BSB 5030 Prediluted Ready-To-Use 7.0 ml
BSB 5031 Prediluted Ready-To-Use 15.0 ml
BSB 5032 Concentrated 1:250-1:1000 0.1 ml
BSB 5033 Concentrated 1:250-1:1000 0.5 ml
BSB 5034 Concentrated 1:250-1:1000 1.0 ml
BSB 5035 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.


There are no reviews yet.

Be the first to review “Actin, Smooth Muscle”

Your email address will not be published.

Related products

Skip to content