Retinoblastoma – MMab

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Ihc Of Retinoblastoma On An Ffpe Colon Carcinoma Tissue

IHC of Retinoblastoma on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationThe retinoblastoma protein (Rb) is a tumor-suppressor protein that is dysfunctional in many types of cancer. One highly studied function of Rb is to prevent excessive cell growth by inhibiting cell-cycle progression until a cell is ready to divide. Rb prevents the cell from replicating damaged DNA by preventing its progression along the cell cycle through G1 into S. Should an oncogenic protein (such as that produced by cells infected with high-risk types of human papillomaviruses, SV40 or Adenoviruses) bind and inactivate Rb, this can lead to cancer. Rb protein may act by regulating transcription; loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and Leukemia.
Antibody TypeMouse MonoclonalClone1F8
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationNuclearControlColon, Breast, Skin, Fallopian Tube, Tonsil, Colon Carcinoma
PresentationAnti-Retinoblastoma is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6127PredilutedReady-To-Use3.0 ml
BSB 6128PredilutedReady-To-Use7.0 ml
BSB 6129PredilutedReady-To-Use15.0 ml
BSB 6130Concentrated1:25-1:1000.1 ml
BSB 6131Concentrated1:25-1:1000.5 ml
BSB 6132Concentrated1:25-1:1001.0 ml
BSB 6133Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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