Retinoblastoma – MMab

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IHC of Retinoblastoma on an FFPE Colon Carcinoma Tissue

IHC of Retinoblastoma on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation The retinoblastoma protein (Rb) is a tumor-suppressor protein that is dysfunctional in many types of cancer. One highly studied function of Rb is to prevent excessive cell growth by inhibiting cell-cycle progression until a cell is ready to divide. Rb prevents the cell from replicating damaged DNA by preventing its progression along the cell cycle through G1 into S. Should an oncogenic protein (such as that produced by cells infected with high-risk types of human papillomaviruses, SV40 or Adenoviruses) bind and inactivate Rb, this can lead to cancer. Rb protein may act by regulating transcription; loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and Leukemia.
Antibody Type Mouse Monoclonal Clone 1F8
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Nuclear Control Colon, Breast, Skin, Fallopian Tube, Tonsil, Colon Carcinoma
Presentation Anti-Retinoblastoma is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6127 Prediluted Ready-To-Use 3.0 ml
BSB 6128 Prediluted Ready-To-Use 7.0 ml
BSB 6129 Prediluted Ready-To-Use 15.0 ml
BSB 6130 Concentrated 1:25-1:100 0.1 ml
BSB 6131 Concentrated 1:25-1:100 0.5 ml
BSB 6132 Concentrated 1:25-1:100 1.0 ml
BSB 6133 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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