3. Ihc Of Pten On A Ffpe Pancreatic Cancer Tissue Webpage

IHC of PTEN on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway.

PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage. Furthermore, PTEN mutation also causes a variety of inherited predispositions to cancer.

Antibody TypeMouse MonoclonalClone6H2.1
IsotypeIgG2aReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlBreast, Prostate, Prostatic & Breast Adenocarcinoma
PresentationPTEN is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3169PredilutedReady-To-Use3.0 ml
BSB 3170PredilutedReady-To-Use7.0 ml
BSB 3171PredilutedReady-To-Use15.0 ml
BSB 3172Concentrated1:25-1:1000.1 ml
BSB 3173Concentrated1:25-1:1000.5 ml
BSB 3174Concentrated1:25-1:1001.0 ml
BSB 3175Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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