PMS2 – RMab

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Ihc Of Pms2 On An Ffpe Colon Carcinoma Tissue

IHC of PMS2 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationPMS2 is a gene that encodes for DNA repair proteins involved in mismatch repair. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells.
Along with MLH1, MSH2 and MSH6, PMS2 is helpful in diagnosing MSI. Tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with none and tumors with high-level MSI.
Antibody TypeRabbit MonoclonalCloneEP51
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlColon Mucosa, Colon Carcinoma
PresentationPMS2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2119PredilutedReady-To-Use3.0 ml
BSB 2120PredilutedReady-To-Use7.0 ml
BSB 2121PredilutedReady-To-Use15.0 ml
BSB 2122Concentrated1:25-1:1000.1 ml
BSB 2123Concentrated1:25-1:1000.5 ml
BSB 2124Concentrated1:25-1:1001.0 ml
BSB 2125Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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