NKX3.1 – RMab

2. Ihc Of Nkx3.1 On A Ffpe Prostatatic Carcinoma Tissue Webpage

IHC of NKX3.1 on an FFPE Prostatic Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Homeobox protein NKX3.1, also known as BAPX2 and NKX3A is a protein that in humans is encoded by the NKX3.1 gene located on chromosome 8p. NKX3.1 is a prostatic tumor suppressor gene, which is an androgen-regulated, prostate-specific homeobox gene whose expression is predominantly localized in the prostate epithelium. It is a negative regulator of epithelial cell growth in prostate tissue. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia. NKX3-1 expression is seen in prostate epithelium, testis, ureter, and pulmonary bronchial mucous glands.

NKX3-1 has been established as a marker for identifying metastatic tumors. In a study the sensitivity for identifying metastatic Prostatic Adenocarcinomas was 98.6% for NKX3.1, 94.2% for PSA and 98.6% for PSAP and specificity of 99.7% for NKX3.1. NKX3.1-positive prostate carcinoma cells exhibit nuclear staining. Additionally, most cases of Urothelial Carcinoma have been found to be negative for NKX3.1 and may be helpful to distinguish between high grade Prostate Adenocarcinoma and high grade Infiltrating Urothelial Carcinoma. NKX3.1 has also been found to be expressed in Invasive Ductal Carcinomas (IDC) and Invasive Lobular Carcinomas (ILC) of the breast. NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC. NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between Prostate Carcinoma and Urothelial Carcinomas.

Antibody TypeRabbit MonoclonalCloneEP356
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlProstate, Prostate Carcinoma
PresentationNKX3.1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3113PredilutedReady-To-Use3.0 ml
BSB 3114PredilutedReady-To-Use7.0 ml
BSB 3115PredilutedReady-To-Use15.0 ml
BSB 3116Concentrated1:50-1:2000.1 ml
BSB 3117Concentrated1:50-1:2000.5 ml
BSB 3118Concentrated1:50-1:2001.0 ml
BSB 3119Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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