MSH2 – MMab

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Hc Of Msh2 On An Ffpe Colon Carcinoma Tissue

IHC of MSH2 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationMSH2 is a mismatch repair gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. When cloned, it is a human homolog of the E. coli DNA mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 is abnormally deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition found in Hereditary Non-Polyposis Colon Cancer. This anti-MSH2 antibody (along with MLH1 antibody) is useful in screening patients and families for this rare condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Antibody TypeMouse MonoclonalCloneG219-1129
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationNuclearControlColon, Skin, Breast, Tonsil, Fallopian Tube, Colon Carcinoma
PresentationAnti-MSH2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5771PredilutedReady-To-Use3.0 ml
BSB 5772PredilutedReady-To-Use7.0 ml
BSB 5773PredilutedReady-To-Use15.0 ml
BSB 5774Concentrated1:50-1:2000.1 ml
BSB 5775Concentrated1:50-1:2000.5 ml
BSB 5776Concentrated1:50-1:2001.0 ml
BSB 5777Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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