Melanoma Cocktail – MMab

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Ihc Of Melanoma Cocktail On An Ffpe Melanoma Tissue

IHC of Melanoma Cocktail on an FFPE Melanoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationHMB-45 reacts against an antigen present in immature melanosomes, cutaneous, melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. This antibody is very useful to identify Malignant Melanoma.
MART-1/Melan-A is a protein antigen found on melanocytes. Antibodies against this antigen are used to recognize cells of melanocytic differentiation, useful for the diagnosis of Melanoma. The same name is used to refer to the gene which codes for this antigen. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation.
The MART-1/Melan-A antigen is specific for the melanocyte lineage found in normal skin, retina, and melanocytes, but not in other normal tissues. It is thus useful as a marker for Melanocytic Tumors, with the caveat that it is normally found in benign nevi as well. Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as Malignant Melanoma and Melanotic Neurofibroma. Essentially no carcinomas express this marker. Melanoma cocktail HMB-45, Mart-1 and Tyrosinase are ideally suited to detect melanomas and melanocytic lesions and may prove to be a valuable marker for melanoma metastasis in sentinel lymph nodes.
Antibody TypeMouse MonoclonalCloneHMB-45, A103 & BSB-6
IsotypeIgG1/K, IgG1 & IgG2aReactivityParaffin, Frozen
LocalizationCytoplasmicControlSkin, Melanoma
PresentationMelanoma Cocktail is a mouse monoclonal antibody cocktail derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6877PredilutedReady-To-Use3.0 ml
BSB 6878PredilutedReady-To-Use7.0 ml
BSB 6879PredilutedReady-To-Use15.0 ml
BSB 6880Concentrated1:100-1:5000.1 ml
BSB 6881Concentrated1:100-1:5000.5 ml
BSB 6882Concentrated1:100-1:5001.0 ml
BSB 6883Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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