IHC of MCM5 on an FFPE Cervical Cancer Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | DNA replication licensing factor MCM5 is a member of the MCM family and is responsible for regulating DNA replication. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. MCM5 is upregulated in the transition from the G0 to the G1/S phase of the cell cycle and may actively participate in cell cycle regulation. MCM5 may be a useful marker for skin cancer, colon cancer, and is of prognostic value in colon cancer and ovarian cancer. |
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| Antibody Type | Rabbit Monoclonal | Clone | RBT-MCM5 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | Control | Tonsil, Testis, Breast, colon, Spleen, Cervical Carcinoma, Colon Carcinoma, Trasitional Cell Carcinoma, Lymphoblastic Lymphoma | |||||||||||||||||||||||||||||||||
| Presentation | MCM5 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
