IHC of MCM5 on an FFPE Cervical Cancer Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||DNA replication licensing factor MCM5 is a member of the MCM family and is responsible for regulating DNA replication. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. MCM5 is upregulated in the transition from the G0 to the G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
MCM5 may be a useful marker for skin cancer, colon cancer, and is of prognostic value in colon cancer and ovarian cancer.
|Antibody Type||Rabbit Monoclonal||Clone||RBT-MCM5|
|Localization||Nuclear||Control||Tonsil, Testis, Breast, colon, Spleen, Cervical Carcinoma, Colon Carcinoma, Trasitional Cell Carcinoma, Lymphoblastic Lymphoma|
|Presentation||MCM5 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|