Kappa Light Chains – MMab

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Ihc Of Kappa On An Ffpe Tonsil Tissue

IHC of Kappa on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationKappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, Kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulin. When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a kappa-lambda ratio greater than or equal to 3:1, a lambda-kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population.
Antibody TypeMouse MonoclonalCloneBSB-58
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlTonsil, Lymph Node
PresentationKappa is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5701PredilutedReady-To-Use3.0 ml
BSB 5702PredilutedReady-To-Use7.0 ml
BSB 5703PredilutedReady-To-Use15.0 ml
BSB 5704Concentrated1:250-1:10000.1 ml
BSB 5705Concentrated1:250-1:10000.5 ml
BSB 5706Concentrated1:250-1:10001.0 ml
BSB 5707Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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