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iNOS – RMab

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iNOS-40X-1GEL02-1-1 Liver

IHC of iNOS on an FFPE Liver Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
The inducible isoform iNOS produces large amounts of NO as a defense mechanism. It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack by parasites, bacterial infection, and tumor growth. It is also the cause of septic shock and may play a role in many diseases with an autoimmune etiology. Induction of the high-output iNOS usually occurs in an oxidative environment, and thus high levels of NO have the opportunity to react with superoxide leading to peroxynitrite formation and cell toxicity. These properties may define the roles of iNOS in host immunity, enabling its participation in anti-microbial and anti-tumor activities as part of the oxidative burst of macrophages.
Antibody Type Rabbitt Monoclonal Clone RBT-iNOS
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Testis, Adrenal, Lung, Prostate, Liver, Placenta, Spleen
Presentation
Histone H3 Phospho is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2656 Prediluted Ready-To-Use 3.0 ml
BSB 2657 Prediluted Ready-To-Use 7.0 ml
BSB 2658 Prediluted Ready-To-Use 15.0 ml
BSB 2659 Concentrated 1:25-1:100 0.1 ml
BSB 2660 Concentrated 1:25-1:100 0.5 ml
BSB 2661 Concentrated 1:25-1:100 1.0 ml
BSB 2662 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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