INI-1 – MMab

Ihc Of Ini-1 On An Ffpe Ewing’s Sarcoma Tissue

IHC of INI-1 on an FFPE Ewing’s Sarcoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationThe INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/ SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing.
The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratenorial primitive neuroectodermal tumors (sPNETs)) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
Antibody TypeMouse MonoclonalClone25
IsotypeIgG2aReactivityParaffin, Frozen
LocalizationNuclearControlTestis, Brain, Breast, Colon, Kidney, Pituitary, Adrenal, Prostate, Thyroid, Lung, Pancreas, Cervix, Salivary Gland, Astrocytoma, Lymphoblastic Lymphoma, Transitional Cell Carcinoma
PresentationINI-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6828PredilutedReady-To-Use3.0 ml
BSB 6829PredilutedReady-To-Use7.0 ml
BSB 6830PredilutedReady-To-Use15.0 ml
BSB 6831Concentrated1:25-1:1000.1 ml
BSB 6832Concentrated1:25-1:1000.5 ml
BSB 6833Concentrated1:25-1:1001.0 ml
BSB 6834Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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