HER-3 – RMab

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Hc Of Her-3 On An Ffpe Colon Tissue

IHC of HER-3 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and ExplanationReceptor tyrosine-protein kinase erbB-3, also known as HER-3 (Human Epidermal Growth Factor Receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. HER-3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. HER-3 can heterodimerize with any of the other three ErbB family members.
During human development, HER-3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium and is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. HER-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. While no evidence has been found that HER-3 overexpression, constitutive activation, or mutation alone is oncogenic, the protein as a heterodimerization partner, most critically with HER-2, is implicated in growth, proliferation, resistance, and the promotion of invasion and metastasis.
Antibody TypeRabbit MonoclonalCloneRBT-HER3
IsotypeIgGReactivityParaffin, Frozen
Colon, Cervix, Bladder TCC
PresentationHER-3 is a rabbit monoclonal antibody derived from cell culture supernatant thatis concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2629PredilutedReady-To-Use3.0 ml
BSB 2630PredilutedReady-To-Use7.0 ml
BSB 2631PredilutedReady-To-Use15.0 ml
BSB 2632Concentrated1:25-1:1000.1 ml
BSB 2633Concentrated1:25-1:1000.5 ml
BSB 2634Concentrated1:25-1:1001.0 ml
BSB 2635Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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