FOXA1 / HNF-3A – Rabbit Polyclonal

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IHC of FOXA1 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationFOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. FOXA1 is a downstream target of GATA3 in the mammary gland.
FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 absence in ERα+ cancer might identify ERa cancers that are resistant to endocrine therapy. In ERα− breast cancer, FOXA1 is highly correlated with improved disease free survival and GATA3. Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.
Antibody TypeRabbit PolyclonalClonePolyclonal
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclear, CytoplasmicControlBreast, Prostate, Tonsil, Breast Carcinoma, Prostate Carcinoma, Bladder TCC
PresentationFOXA1 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6744PredilutedReady-To-Use3.0 ml
BSB 6745PredilutedReady-To-Use7.0 ml
BSB 6746PredilutedReady-To-Use15.0 ml
BSB 6747Concentrated1:25-1:1000.1 ml
BSB 6748Concentrated1:25-1:1000.5 ml
BSB 6749Concentrated1:25-1:1001.0 ml
BSB 6750Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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