Cytokeratin HMW 34BetaE12 – MMab

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IHC of CK34BE12 on an FFPE Prostate Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratin 34βE12 is a High Molecular Weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins 1, 5, 10, and 14 that are found in complex epithe-lia. Cytokeratin 34βE12 shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules or endometrial glands; there has been no reactivity with cells derived from simple epithelia. Nerve cells, glial cells and mesenchymal tissue such as blood vessels containing only non-keratin types of intermediate filaments are not labelled; however, reactivity with smooth-muscle cells has been occasionally observed. Mesenchymal Tumors, Lymphomas, Melanomas, Neural Tumors and Neuroendocrine Tumors are unreactive with this antibody. Cytokeratin 34βE12 has been shown to be useful in distinguishing Prostatic Adenocarcinoma from Hyperplasia of the Prostate.
Antibody Type Mouse Monoclonal Clone 34BE12
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Prostate, Cervix
Presentation Cytokeratin 34βE12 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5393 Prediluted Ready-To-Use 3.0 ml
BSB 5394 Prediluted Ready-To-Use 7.0 ml
BSB 5395 Prediluted Ready-To-Use 15.0 ml
BSB 5396 Concentrated 1:50-1:200 0.1 ml
BSB 5397 Concentrated 1:50-1:200 0.5 ml
BSB 5398 Concentrated 1:50-1:200 1.0 ml
BSB 5399 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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