Claudin-5 – RMab

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Claudin 5

IHC of Claudin-5 on an FFPE Liver Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationClaudin-5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin-5 have been found in patients with velocardiofacial syndrome.
Claudin-5 labels endothelial cells and has been used as a marker for endothelial lesions. Claudin-5 is also found in bronchial and lung epithelial cells. In tumors, Claudin-5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior.
Antibody TypeRabbit MonoclonalCloneEP224
IsotypeIgGReactivityParaffin, Frozen
LocalizationMembranousControlLiver, Vascular Tissue, Placenta, Colon, Kidney, Fallopian Tube
PresentationClaudin-5 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2398PredilutedReady-To-Use3.0 ml
BSB 2399PredilutedReady-To-Use7.0 ml
BSB 2400PredilutedReady-To-Use15.0 ml
BSB 2401Concentrated1:25-1:1000.1 ml
BSB 2402Concentrated1:25-1:1000.5 ml
BSB 2403Concentrated1:25-1:1001.0 ml
BSB 2404Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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