CD45RO – MMab

Cd3 Rmab

IHC of CD45 RO on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationThe CD45 family consists of multiple members that are all products of a single complex gene. Three isoforms of CD45 exist: on B-lymphocytes, where the protein is called B220 (its molecular mass is 220 kDA); on naive T-lymphocytes, where it is called CD45 RA, and on activated and memory T-lymphocytes, where it is called CD45 RO. CD45RO is a single-chain, transmembraneous glycoprotein which represents the low molecular weight isoform of the Leukocyte Common Antigen (LCA). It is expressed on most thymocytes, about 45% of peripheral blood T-cells, virtually all T-cells in skin reactive infiltrates, and the majority of T-cell malignancies. It is also found on a subset of B-cells and on exceptional B-cell Lymphomas. CD45RO (T-Cell, Pan) antibody reacts with thymocytes and activated T-cells, but only on a subpopulation of resting T-cells. This antibody shows no reactivity with B-cells, making it a good marker for T-cell tumors to be phenotyped. In addition, granulocytes and monocytes are also labeled with this antibody. T-Cell, Pan has been designated as CD45RO at The International Leukocyte Typing Workshop.
Antibody TypeMouse MonoclonalCloneUCHL-1
IsotypeIgG2a/KReactivityParaffin, Frozen
LocalizationMembranousControlTonsil, Lymph Node
PresentationCD45RO is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5260PredilutedReady-To-Use3.0 ml
BSB 5261PredilutedReady-To-Use7.0 ml
BSB 5262PredilutedReady-To-Use15.0 ml
BSB 5263Concentrated1:250-1:10000.1 ml
BSB 5264Concentrated1:250-1:10000.5 ml
BSB 5265Concentrated1:250-1:10001.0 ml
BSB 5266Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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