bcl6 – MMab

Ihc Of Bcl6 On An Ffpe Colon Tissue

IHC of bcl6 on a FFPE Colon Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanationbcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease. bcl-6 is also useful in identifying neoplastic cells in cases of nodular Lymphocyte-Predominant Hodgkin’s Disease.

In contrast, anti-bcl-6 rarely stains Mantle-Cell Lymphoma and MALT Lymphoma. bcl-6 expression is seen in approximately 45% of CD30+ Anaplastic Large-Cell Lymphomas but is consistently absent in other peripheral T-cell Lymphomas.

Antibody TypeMouse MonoclonalCloneBSB-26
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationNuclearControlTonsil, Lymph Node, Thymus, Skin, Breast, Brain, Follicular Lymphoma
Presentationbcl6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3434PredilutedReady-To-Use3.0 ml
BSB 3435PredilutedReady-To-Use7.0 ml
BSB 3436PredilutedReady-To-Use15.0 ml
BSB 3437Concentrated1:100-1:5000.1 ml
BSB 3438Concentrated1:100-1:5000.5 ml
BSB 3439Concentrated1:100-1:5001.0 ml
BSB 3440Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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