Melanosome – MMab

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IHC of Melanoma / HMB-45 on an FFPE Malignant Melanoma Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation HMB-45 reacts against an antigen present in immature melanosomes, cutaneous melanocytes, prenatal and infantile retinal pigment epithelium cells. This antibody was generated to an extract of Melanoma. It reacted positively against Melanocytic Tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, this antibody reacts positively against juntional nebus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes.This antibody is very useful to identify Malignant Melanoma. Metastatic Amelanotic Melanoma can often be confused with a variety of poorly differentiated Carcinomas, Large Cell Lymphomas, Sarcomas, Spindle Cell Carcinomas and various types of mesenchymal neoplasms. A keratin-negative, vimentin-rich neoplasm that immunoreacts with antibody to S-100 protein and with this melanoma antibody, is, with rare exception, a Melanoma.
Antibody Type Mouse Monoclonal Clone HMB-45
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Melanoma
Presentation HMB-45 Melanoma antibody is a mouse monoclonal from tissue culture supernatant that is diluted in Phosphate Buffered Saline, pH 7.6, with protein base, and preserved with Sodium Azide preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5757 Prediluted Ready-To-Use 3.0 ml
BSB 5758 Prediluted Ready-To-Use 7.0 ml
BSB 5759 Prediluted Ready-To-Use 15.0 ml
BSB 5760 Concentrated 1:250-1:1000 0.1 ml
BSB 5761 Concentrated 1:250-1:1000 0.5 ml
BSB 5762 Concentrated 1:250-1:1000 1.0 ml
BSB 5763 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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