CD19 – MMab


IHC of CD19 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation CD19 is a human protein encoded by the CD19 gene. CD19 is expressed on follicular dendritic cells and B-cells; it is present on B-cells from earliest recognizable B-lineage cells during development to B-cell blasts, but is lost on maturation to plasma cells. In normal lymphoid tissue, CD19 is observed in germinal centers (on both B-cells and follicular dendritic cells), in mantle-zone cells, and in scattered cells in the interfollicular areas, with an overall immunoreactivity pattern similar to that ofCD20 and CD22. However, in contrast to CD20, CD19 is also expressed in pre-B-cells. CD19 positivity is seen in the vast majority of B-cell neoplasms (B-Lymphoblastic Lymphoma, Small Lym-phocytic Lymphoma/CLL, Mantle Cell Lymphoma, Follicular Lymphoma, Burkitt’s Lymphoma, Marginal Zone Lymphoma, Diffuse Large B-cell Lymphoma, T-cell-rich B-cell Lymphoma, Lymphoblastic Lymphoma, Hairy Cell Leukemia), and commonly at a lower intensity than normal B-cell elements. Plasma cell neoplasms are consistently negative, as are T-cell neoplasms. CD19 expression is not seen in Reed-Sternberg cells of classic Hodgkin’s Disease.
Antibody Type Mouse Monoclonal Clone BSB-97
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Membranous Control Tonsil, Lymph Node, Spleen, Colon
Presentation CD19 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6226 Prediluted Ready-To-Use 3.0 ml
BSB 6227 Prediluted Ready-To-Use 7.0 ml
BSB 6228 Prediluted Ready-To-Use 15.0 ml
BSB 6229 Concentrated 1:25-1:100 0.1 ml
BSB 6230 Concentrated 1:25-1:100 0.5 ml
BSB 6231 Concentrated 1:25-1:100 1.0 ml
BSB 6232 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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