Parafibromin – MMab

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Ihc Of Parafibromin On An Ffpe Parathyroid Carcinomatissue

IHC of Parafibromin on an FFPE Parathyroid Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and ExplanationCell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S.cerevisiae), also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene. Mutations in the CDC73 gene are associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid carcinomas.The proposed role of HRPT2 as a tumor suppressor was supported by mutation screening in parathyroid adenomas with cystic features, which identified three somatic inactivating mutations, all located in exon 1. None of these mutations were detected in normal controls, and all were predicted to cause deficient or impaired protein function. Sporadic parathyroid carcinomas frequently have HRPT2 mutations that are likely to be of pathogenetic importance. Certain patients with apparently sporadic parathyroid carcinoma carry germ-line mutations in HRPT2 and may have the HPT-JT syndrome or a phenotypic variant.
Antibody TypeMouse MonoclonalCloneBSB-50
IsotypeIgG1ReactivityParaffin, Frozen
Parathyroid, Colon, Testis, Adrenal, Breast, Cervix, Lymphoblastic Lymphoma, Bladder TCC
PresentationParafibromin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2747PredilutedReady-To-Use3.0 ml
BSB 2748PredilutedReady-To-Use7.0 ml
BSB 2749PredilutedReady-To-Use15.0 ml
BSB 2750Concentrated1:25-1:1000.1 ml
BSB 2751Concentrated1:25-1:1000.5 ml
BSB 2752Concentrated1:25-1:1001.0 ml
BSB 2753Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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