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Parafibromin – MMab

SKU: 32b73948d9dd Categories: , ,

IHC of Parafibromin on an FFPE Parathyroid CarcinomaTissue

IHC of Parafibromin on an FFPE Parathyroid Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S.cerevisiae), also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene. Mutations in the CDC73 gene are associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid carcinomas.The proposed role of HRPT2 as a tumor suppressor was supported by mutation screening in parathyroid adenomas with cystic features, which identified three somatic inactivating mutations, all located in exon 1. None of these mutations were detected in normal controls, and all were predicted to cause deficient or impaired protein function. Sporadic parathyroid carcinomas frequently have HRPT2 mutations that are likely to be of pathogenetic importance. Certain patients with apparently sporadic parathyroid carcinoma carry germ-line mutations in HRPT2 and may have the HPT-JT syndrome or a phenotypic variant.
Antibody Type Mouse Monoclonal Clone BSB-50
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Nuclear Control
Parathyroid, Colon, Testis, Adrenal, Breast, Cervix, Lymphoblastic Lymphoma, Bladder TCC
Presentation Parafibromin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2747 Prediluted Ready-To-Use 3.0 ml
BSB 2748 Prediluted Ready-To-Use 7.0 ml
BSB 2749 Prediluted Ready-To-Use 15.0 ml
BSB 2750 Concentrated 1:25-1:100 0.1 ml
BSB 2751 Concentrated 1:25-1:100 0.5 ml
BSB 2752 Concentrated 1:25-1:100 1.0 ml
BSB 2753 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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